Original price was: $700.00.Current price is: $600.00.

100% Authentic Increlex (Mecasermin) IGF-1
Pharmaceutical-Grade Purity with COA & Lab Reports
Bulk & Wholesale Supply Available
Fast, Discreet Worldwide Shipping

FDA Approved: Yes (First approved August 30, 2005)
Concentration: 10mg/ml
Generic name: mecasermin
Dosage form: Injection
Volume:1ml Vial
Treatment for: Primary IGF-1 Deficiency

What is Increlex?

Increlex (mecasermin) is a prescription medication manufactured by Ipsen Biopharmaceuticals containing recombinant human insulin-like growth factor-1 (IGF-1). It is identical to the IGF-1 naturally produced by the human body and plays a critical role in growth, development, and tissue repair.

Unlike human growth hormone (HGH), which stimulates IGF-1 production in the liver, Increlex provides direct IGF-1 supplementation. This bypasses the HGH→IGF-1 conversion step, delivering immediate anabolic effects. Each vial contains 10mg of pure mecasermin in a ready-to-use liquid formulation.

  • Active Ingredient – Mecasermin (recombinant human IGF-1)
  • Molecular Structure – 70 amino acids (identical to natural IGF-1)
  • Purity≥ 99% (Pharmaceutical Grade)
  • Formulation – Liquid Solution (no reconstitution needed)
  • Bioavailability~100% (subcutaneous)
  • Half-Life – 12-15 hours
  • Storage – Refrigerate 2-8°C (36-46°F)

Critical Safety Information

Increlex can cause severe hypoglycemia (low blood sugar). Must be taken with food. Not for use in patients with active malignancy. Monitor blood glucose regularly. This product requires refrigeration—cold chain must be maintained.

Increlex Benefits & Mechanism

Muscle Hyperplasia

IGF-1 stimulates satellite cell activation and muscle fiber splitting, creating NEW muscle cells (hyperplasia) rather than just enlarging existing ones. This permanent increase in muscle cell count provides lasting gains.

Rapid Recovery

Dramatically accelerates tissue repair and regeneration. Reduces DOMS (delayed onset muscle soreness) and allows for more frequent, intense training sessions. Connective tissue strength improves significantly.

Nutrient Partitioning

IGF-1 acts as a “partitioning agent,” directing nutrients toward muscle tissue and away from fat storage. Enhances insulin sensitivity in muscle cells while promoting fat oxidation.

Cellular Regeneration

Promotes regeneration of nerves, skin, and internal organs. Accelerates healing of injuries, burns, and surgical sites. Anti-aging effects on skin, hair, and connective tissues.

Cognitive Enhancement

IGF-1 crosses the blood-brain barrier and supports neurogenesis. Users report improved focus, memory, and mental clarity. Neuroprotective effects may reduce risk of neurodegenerative conditions.

Immune Modulation

Enhances immune cell function and supports the body’s defense mechanisms. Particularly beneficial for individuals with compromised immune systems or those undergoing intensive physical stress.

IGF-1 vs HGH: Understanding the Difference

HGH (Somatropin)

  • Stimulates liver to produce IGF-1
  • Indirect anabolic effects
  • Longer time to see results (4-6 weeks)
  • Broader systemic effects
  • Requires daily injections
  • More affordable option

IGF-1 (Mecasermin)

  • Direct anabolic hormone action
  • Immediate effects on muscle tissue
  • Results visible in days (not weeks)
  • Localized and systemic effects
  • Multiple injections per day
  • Premium pharmaceutical grade

Increlex Dosage Protocols

Proper dosing is critical for results and safety. Increlex is significantly more potent than HGH and requires careful titration. Always start at the lowest effective dose.

Protocol Dose per Injection Frequency Best For
Medical (Pediatric IGFD) 40-80 mcg/kg Twice daily (BID) Growth failure treatment
Beginner Bodybuilding 40-60 mcg Once daily post-workout First-time IGF-1 users
Intermediate Protocol 50-100 mcg 2x daily (PWO & bedtime) Muscle growth & recovery
Advanced Protocol 100-150 mcg 2-3x daily Maximum anabolic effect
Localized Protocol 20-40 mcg Intramuscular to target muscle Site-specific growth

Critical Administration Guidelines

  • ALWAYS take with carbohydrates—IGF-1 can cause severe hypoglycemia
  • Inject subcutaneously or intramuscularly (IM for site-specific growth)
  • Best timing: Post-workout with post-workout meal, and before bed
  • Rotate injection sites to prevent lipohypertrophy
  • Never exceed 200 mcg per day without medical supervision
  • Cycle 4-6 weeks on, 4-6 weeks off to maintain sensitivity
  • Monitor blood glucose—keep fast-acting carbs available

Clinical Research & Evidence

FDA Approval & Pediatric Studies

Increlex received FDA approval in 2005 for treatment of severe primary IGF-1 deficiency. Clinical trials demonstrated:

  • Significant height velocity improvement in 90%+ of patients
  • Normalized IGF-1 levels within 6 months
  • Improved bone mineral density
  • Well-tolerated long-term (up to 10 years in extension studies)
  • Quality of life improvements in physical function

IGF-1 in Muscle Biology

Peer-reviewed research on IGF-1 and muscle growth shows:

  • Activates satellite cells for muscle fiber regeneration
  • Stimulates mTOR pathway for protein synthesis
  • Increases muscle cell number (hyperplasia), not just size
  • Enhances glucose uptake and glycogen synthesis
  • Reduces muscle protein breakdown (anti-catabolic)

Expected Results Timeline

Days 1-3: Immediate Effects

Enhanced muscle pumps, improved nutrient uptake, better sleep quality

Week 1-2: Recovery Enhancement

Dramatically reduced DOMS, faster healing, increased training frequency capacity

Weeks 3-4: Visible Changes

Noticeable muscle fullness, strength increases, body recomposition

Weeks 8-12: Maximum Benefits

Significant lean mass gains, permanent muscle cell increase, optimized body composition

Increlex Side Effects & Risk Management

Critical: Hypoglycemia Risk

The most serious side effect of Increlex is hypoglycemia (low blood sugar). IGF-1 mimics insulin’s effects and can drop blood glucose dangerously low, especially when taken without adequate carbohydrates.

Symptoms of Hypoglycemia:

  • Dizziness, lightheadedness, confusion
  • Excessive sweating, tremors, palpitations
  • Hunger, irritability, weakness
  • Blurred vision, headache
  • In severe cases: loss of consciousness

Prevention: Always consume 30-50g fast-acting carbs with each injection. Keep glucose tablets or juice available. Monitor blood glucose if diabetic or hypoglycemic.

Other Common Side Effects

  • Injection site reactions: Bruising, pain, lipohypertrophy
  • Tonsillar hypertrophy: Enlarged tonsils (more common in children)
  • Headache: Usually mild, transient
  • Joint pain: Similar to HGH joint discomfort
  • Fluid retention: Mild edema in extremities
  • Hypothyroidism: May suppress natural thyroid function

Serious Risks (Rare)

  • Intracranial hypertension (increased pressure in skull)
  • Accelerated growth of existing tumors
  • Organomegaly with prolonged high-dose use
  • Severe allergic reactions (anaphylaxis)

Contraindications & Precautions

DO NOT USE IF:

  • Active cancer/malignancy
  • Diabetic ketoacidosis
  • Hypersensitivity to mecasermin
  • Closed epiphyses (growth plates)

USE WITH CAUTION:

  • Diabetes or pre-diabetes
  • History of hypoglycemia
  • Thyroid disorders
  • Kidney or liver disease

MONITORING NEEDED:

  • Fasting blood glucose
  • HbA1c levels
  • IGF-1 serum levels
  • Thyroid function (TSH)

Frequently Asked Questions

What is Increlex used for?

Increlex (mecasermin) is FDA-approved for long-term treatment of growth failure in children with severe primary IGF-1 deficiency (Primary IGFD) or with growth hormone gene deletion who have developed neutralizing antibodies to GH. Off-label, it’s used by bodybuilders and athletes for muscle hyperplasia, enhanced recovery, nutrient partitioning, and performance enhancement due to its potent anabolic effects.

What is the difference between IGF-1 and HGH?

HGH (Human Growth Hormone) is produced by the pituitary gland and stimulates the liver to produce IGF-1. IGF-1 (Insulin-like Growth Factor-1) is the hormone that actually mediates most of HGH’s growth-promoting effects. While HGH stimulates IGF-1 production, taking IGF-1 directly (as Increlex) bypasses this step and provides immediate anabolic effects. IGF-1 is more potent for localized muscle growth and hyperplasia, works faster, but requires multiple daily injections and careful management of blood sugar.

How do you take Increlex Mecasermin?

Increlex is administered via subcutaneous injection. For medical use in children: 40-80 mcg/kg twice daily, titrated up to max 120 mcg/kg twice daily. For bodybuilding: typically 50-150 mcg per day, often split into 2-3 doses. Best taken post-workout and before bed. MUST be administered with food to prevent hypoglycemia—consume 30-50g carbohydrates with each injection. Rotate injection sites to prevent lipodystrophy. Never use without food.

How long does Increlex take to work?

IGF-1 works significantly faster than HGH. Users typically report enhanced pumps and muscle fullness within 3-7 days. Visible muscle growth and strength improvements become noticeable after 2-4 weeks. Maximum benefits for muscle hyperplasia and recovery are achieved after 8-12 weeks of consistent use. Unlike HGH which has cumulative effects, IGF-1 provides immediate anabolic signaling. Results are dose-dependent and enhanced with proper training and nutrition.

Is Increlex better than IGF-1 LR3?

Increlex contains native sequence human IGF-1 (mecasermin), which is identical to the body’s natural IGF-1. IGF-1 LR3 is a modified version with extended half-life but reduced binding affinity to IGF binding proteins. Increlex is pharmaceutical grade with guaranteed purity, potency, and sterility, manufactured by Ipsen under FDA regulations. IGF-1 LR3 is typically research-grade with variable quality. Increlex provides more predictable results, proper clinical dosing, and is preferred for medical-grade protocols. However, LR3 requires fewer injections due to longer half-life.

Can Increlex be stacked with HGH?

Yes, but with extreme caution. Stacking IGF-1 with HGH creates a synergistic effect for muscle growth but significantly increases side effect risks, especially hypoglycemia, organ growth, and insulin resistance. If stacking, doses of both should be reduced by at least 50%. Proper monitoring of blood glucose, IGF-1 levels, and organ function is essential. Most experts recommend using one or the other, not both simultaneously. The combination is generally reserved for advanced users under medical supervision.

How should Increlex be stored?

Increlex vials must be refrigerated at 2-8°C (36-46°F) at all times. Do not freeze—freezing destroys the protein structure. Protect from light. Unlike HGH which is lyophilized powder, Increlex is a liquid solution and is more sensitive to temperature fluctuations. Once opened, vials should be used within 30 days. Always check for particles or discoloration before use—discard if present. Maintain cold chain during shipping is critical. Room temperature exposure should be limited to less than 30 minutes.

Why is Increlex so expensive?

Increlex is expensive due to several factors: (1) It’s a biologic drug produced using recombinant DNA technology in specialized facilities, (2) It’s manufactured to pharmaceutical grade standards with extensive quality control, (3) It’s an orphan drug for rare conditions with limited production runs, (4) Cold chain distribution adds logistical costs, (5) FDA approval and regulatory compliance requirements. The price reflects guaranteed purity, potency, sterility, and clinical-grade manufacturing that research chemicals cannot match.